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News from Toho TOPICS Pharmaceutical Sciences DATE February  20, 2024 Conducting Research at Toho SHARE February 20, 2024 Platelet activating factor (PAF), a bioactive phospholipid, strongly contracts esophageal smooth muscle Dr. Keisuke Obara(left), Prof. Yoshio Tanaka(center),Dr. Kento Yoshioka(right) A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka of the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, found that platelet activating factor (PAF), a bioactive phospholipid, strongly contracts esophageal smooth muscle (ESM). In addition, the researchers also revealed that PAF-induced ESM contractions are elicited by extracellular Ca2+ influx through receptor-operated Ca2+ channels (ROCCs) and store-operated Ca2+ channels (SOCCs), but not through voltage-dependent Ca2+ channels (VDCCs). These findings were published in advance in the journal &#8220;Journal of Pharmacological Sciences&#8221; on February 16, 2024. Dr. Keisuke Obara(left), Prof. Yoshio Tanaka(center), Dr. Kento Yoshioka(right) A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka of the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, found that platelet activating factor (PAF), a bioactive phospholipid, strongly contracts esophageal smooth muscle (ESM). In addition, the researchers also revealed that PAF-induced ESM contractions are elicited by extracellular Ca2+ influx through receptor-operated Ca2+ channels (ROCCs) and store-operated Ca2+ channels (SOCCs), but not through voltage-dependent Ca2+ channels (VDCCs). These findings were published in advance in the journal &#8220;Journal of Pharmacological Sciences&#8221; on February 16, 2024. Representative traces (A) and summarized data (B) showing the effects of PAF (10−9 M, a; 10−8 M, b; 10−7 M, c; 10−6 M, d) on isolated guinea pig esophageal muscularis mucosae. CLICK HERE TO FIND OUT MORE RELATED NEWS-Pharmaceutical Sciences: Detection of high concentrations of D-amino acids and D-lactate in estuarine polychaetes ~ Implications for the life activities of polychaetes? ~ Detection of high concentrations of D-amino acids and D-lactate in estuarine polychaetes ~ Implications for the life activities of polychaetes? ~ • 03/25/2024 • Research The antidepressant nefazodone inhibits acetylcholinesterase —nefazodone could prevent the progression of Alzheimer&#8217;s disease— The antidepressant nefazodone inhibits acetylcholinesterase —nefazodone could prevent the progression of Alzheimer&#8217;s disease— • 02/20/2024 • Research Structure of DNA enzyme that repairs UV-damaged DNA Structure of DNA enzyme that repairs UV-damaged DNA • 10/23/2023 • Research 1 2 3 … 5 Next » ABOUT ACADEMICS RESEARCH ADMISSION CAMPUS LIFE NEWS ABOUT ACADEMICS RESEARCH ADMISSION CAMPUS LIFE NEWS SUPPORTER LOGIN ABOUT &#8211; Founding Spirits &#8211; Message from President &#8211; Facts & Figures &#8211; Global Partners ACADEMICS Undergraduate Programs &#8211; Medicine &#8211; Pharmaceutical Sciences &#8211; Science &#8211; Nursing &#8211; Health Science Graduate Programs &#8211;Medicine &#8211;Pharmaceutical Sciences &#8211;Science &#8211;Nursing RESEARCH&#8211; News&#8211; Guidelines & Policies&#8211; Support Offices&#8211; Facilities&#8211; Security Export Control Non-Degree Programs&#8211; Clinical Elective Program&#8211; International Physician Observership Program ADMISSION&#8211; For applicants&#8211; Scholarships&#8211; Visas NEWS FOR VISITORS @ Toho University Site Policy Privacy Policy

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